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samtools htslib library version 1.4.0 and earlier is vulnerable to buffer overflow in the…

Priority MEDIUM 46CWE-119Published · Updated

Key facts

Attack vector
Network
Privileges required
None
User interaction
None
Attack complexity
Low
Impact type
Code execution
Confidentiality · integrity · availability
High · High · High
Fix status
No fix listed

Attack profile from CVSS 3.0 · NVD. Fix status from CNA. Impact type from CWE-119 and the CVSS impact.

Summary

samtools htslib library version 1.4.0 and earlier is vulnerable to buffer overflow in the CRAM rANS codec resulting in potential arbitrary code execution

Why it matters now

EPSS 0.02228 82nd percentileScored 2026-11-07
Fix No fix listed No fixed version in the sources yet

SSVC decision points

Not available: CISA has not published SSVC decision points for this record.

Affected products

VendorProductAffected versionsFixed inStatusSource
——all versions—No fix listedCNA
  • — Vendor— Affected all versions Fixed in — No fix listed CNA

CPE configurations NVD · 1

CPEVersionsRoleVendor
cpe:2.3:a:htslib:htslib:*:*:*:*:*:*:*:*up to 1.4.0VulnerableHtslib
  • cpe:2.3:a:htslib:htslib:*:*:*:*:*:*:*:* Versions up to 1.4.0 Vulnerable ·Htslib

Remediation

No fixed version listed by the sources yet.

Timeline

  1. 2026-10-02 Threatist record created from CVE-2017-1000206
  2. 2026-10-03 Alias added: GHSA-mfgv-xhqh-pmvp

References

  • TI-2018-10042 An issue has been found in HTSlib 1.8. CVSS 3.0CRITICAL 9.8
  • TI-2026-24512 HTSlib CRAM decoder vulnerable to buffer overflow CVSS 4.0HIGH 8.8
  • TI-2026-24507 HTSlib CRAM reader has heap buffer overflow due to improper validation of input CVSS 4.0HIGH 8.8
  • TI-2026-24506 HTSlib CRAM reader has heap buffer overflow due to improper validation of input CVSS 4.0HIGH 8.8
  • TI-2020-18654 HTSlib through 1.10.2 allows out-of-bounds write access in vcf_parse_format (called from vcf_parse and vcf_read). CVSS 3.1HIGH 8.8
  • TI-2026-24511 HTSlib CRAM reader has out-of-bounds read due to improper validation of input CVSS 4.0MEDIUM 6.9
See all 15 →

Sources