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TI-2024-34054 Aliases CVE-2024-50636GHSA-wq8w-m2g8-mv57

PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the…

Priority HIGH 82CWE-94Published · Updated

Key facts

Attack vector
Network
Privileges required
None
User interaction
None
Attack complexity
Low
Impact type
Code execution
Confidentiality · integrity · availability
High · High · High
Fix status
No fix listed

Attack profile from CVSS 3.1 · CISA ADP. Fix status from CNA. Impact type from CWE-94.

Summary

PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the execution of arbitrary Python code embedded within .PYM files. Attackers can craft a malicious .PYM file containing a Python reverse shell payload and exploit the function to achieve Remote Command Execution (RCE). This vulnerability arises because PyMOL treats .PYM files as Python scripts without properly validating or restricting the commands within the script, enabling attackers to run unauthorized commands in the context of the user running the application.

Why it matters now

Exploitation Proof of concept CISA SSVC · not in CISA KEV
EPSS 0.01246 69th percentileScored 2026-11-07
Fix No fix listed No fixed version in the sources yet

SSVC decision points

CISA ADP · SSVC 2.0.3

Exploitation
Poc
Automatable
Yes
Technical impact
Total

The decision (Track, Attend, Act) also depends on your mission and well-being impact; see CISA's SSVC guide.

Affected products

VendorProductAffected versionsFixed inStatusSource
——all versions—No fix listedCNA
  • — Vendor— Affected all versions Fixed in — No fix listed CNA

CPE names CISA-ADP · 1

CPEVersionsRoleVendor
cpe:2.3:a:schrodinger:pymol:2.5.0:*:*:*:*:*:*:*2.5.0——
  • cpe:2.3:a:schrodinger:pymol:2.5.0:*:*:*:*:*:*:* Versions 2.5.0 — ·—

Remediation

No fixed version listed by the sources yet.

Vendor assessments

Red Hat

Red Hat's page for this CVE →

Not affected: 1 product
  • Red Hat

Timeline

  1. 2026-10-02 Threatist record created from CVE-2024-50636
  2. 2026-10-03 Alias added: GHSA-wq8w-m2g8-mv57

References

Other 3

Sources

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