Unrestricted file upload in Illumina NextSeq 550Dx
Priority MEDIUM 52CWE-434Published · Updated
Key facts
- Attack vector
- Network
- Privileges required
- None
- User interaction
- None
- Attack complexity
- Low
- Impact type
- Code execution
- Confidentiality · integrity · availability
- High · High · High
- Fix status
- No fix listed
Attack profile from CVSS 3.1 · CNA. Fix status from CNA. Impact type from CWE-434.
Summary
LRM does not restrict the types of files that can be uploaded to the affected product. A malicious actor can upload any file type, including executable code that allows for a remote code exploit.
Why it matters now
Exploitation None reported CISA SSVC · not in CISA KEV
EPSS 0.01403 72nd percentileScored 2026-11-07
Fix No fix listed No fixed version in the sources yet
SSVC decision points
CISA ADP · SSVC 2.0.3
- Exploitation
- None
- Automatable
- Yes
- Technical impact
- Total
The decision (Track, Attend, Act) also depends on your mission and well-being impact; see CISA's SSVC guide.
Affected products
| Vendor | Product | Affected versions | Fixed in | Status | Source |
|---|---|---|---|---|---|
| Illumina | NextSeq 550Dx | LRM Versions 1.3 to 3.1 | — | No fix listed | CNA |
| Illumina | MiSeq Dx | LRM Versions 1.3 to 3.1 | — | No fix listed | CNA |
| Illumina | NextSeq 500 Instrument | LRM Versions 1.3 to 3.1 | — | No fix listed | CNA |
| Illumina | NextSeq 550 Instrument | LRM Versions 1.3 to 3.1 | — | No fix listed | CNA |
| Illumina | MiSeq Instrument | LRM Versions 1.3 to 3.1 | — | No fix listed | CNA |
| Illumina | iSeq 100 Instrument | LRM Versions 1.3 to 3.1 | — | No fix listed | CNA |
| Illumina | MiniSeq Instrument | LRM Versions 1.3 to 3.1 | — | No fix listed | CNA |
- NextSeq 550Dx VendorIllumina Affected LRM Versions 1.3 to 3.1 Fixed in — No fix listed CNA
- MiSeq Dx VendorIllumina Affected LRM Versions 1.3 to 3.1 Fixed in — No fix listed CNA
- NextSeq 500 Instrument VendorIllumina Affected LRM Versions 1.3 to 3.1 Fixed in — No fix listed CNA
- NextSeq 550 Instrument VendorIllumina Affected LRM Versions 1.3 to 3.1 Fixed in — No fix listed CNA
- MiSeq Instrument VendorIllumina Affected LRM Versions 1.3 to 3.1 Fixed in — No fix listed CNA
- iSeq 100 Instrument VendorIllumina Affected LRM Versions 1.3 to 3.1 Fixed in — No fix listed CNA
- MiniSeq Instrument VendorIllumina Affected LRM Versions 1.3 to 3.1 Fixed in — No fix listed CNA
CPE configurations NVD · 8
| CPE | Versions | Role | Vendor |
|---|---|---|---|
| cpe:2.3:a:illumina:local_run_manager:*:*:*:*:*:*:*:* | 1.3 – 3.1 | Vulnerable | Illumina |
| cpe:2.3:h:illumina:iseq_100:-:*:*:*:*:*:*:* | not specified by NVD | Running on | Illumina |
| cpe:2.3:h:illumina:miniseq:-:*:*:*:*:*:*:* | not specified by NVD | Running on | Illumina |
| cpe:2.3:h:illumina:miseq:-:*:*:*:*:*:*:* | not specified by NVD | Running on | Illumina |
| cpe:2.3:h:illumina:miseq_dx:-:*:*:*:*:*:*:* | not specified by NVD | Running on | Illumina |
| cpe:2.3:h:illumina:nextseq_500:-:*:*:*:*:*:*:* | not specified by NVD | Running on | Illumina |
| cpe:2.3:h:illumina:nextseq_550:-:*:*:*:*:*:*:* | not specified by NVD | Running on | Illumina |
| cpe:2.3:h:illumina:nextseq_550dx:-:*:*:*:*:*:*:* | not specified by NVD | Running on | Illumina |
- cpe:2.3:a:illumina:local_run_manager:*:*:*:*:*:*:*:* Versions 1.3 – 3.1 Vulnerable ·Illumina
- cpe:2.3:h:illumina:iseq_100:-:*:*:*:*:*:*:* Versions not specified by NVD Running on ·Illumina
- cpe:2.3:h:illumina:miniseq:-:*:*:*:*:*:*:* Versions not specified by NVD Running on ·Illumina
- cpe:2.3:h:illumina:miseq:-:*:*:*:*:*:*:* Versions not specified by NVD Running on ·Illumina
- cpe:2.3:h:illumina:miseq_dx:-:*:*:*:*:*:*:* Versions not specified by NVD Running on ·Illumina
- cpe:2.3:h:illumina:nextseq_500:-:*:*:*:*:*:*:* Versions not specified by NVD Running on ·Illumina
- cpe:2.3:h:illumina:nextseq_550:-:*:*:*:*:*:*:* Versions not specified by NVD Running on ·Illumina
- cpe:2.3:h:illumina:nextseq_550dx:-:*:*:*:*:*:*:* Versions not specified by NVD Running on ·Illumina
Remediation
No fixed version listed by the sources yet.
Timeline
- 2026-10-02 Threatist record created from CVE-2022-1519
- 2026-10-03 Alias added: GHSA-4pg3-x42q-599h
References
More Illumina Local Run Manager vulnerabilities
- TI-2022-01391 3.2.2 IMPROPER LIMITATION OF A PATHNAME TO A RESTRICTED DIRECTORY ('PATH TRAVERSAL') CWE-22 CVSS 3.1CRITICAL 10.0
- TI-2022-01390 3.2.1 EXECUTION WITH UNNECESSARY PRIVILEGES CWE-250 CVSS 3.1CRITICAL 10.0
- TI-2022-01394 3.2.4 IMPROPER ACCESS CONTROL CWE-284 CVSS 3.1CRITICAL 9.1
- TI-2022-01397 3.2.5 CLEARTEXT TRANSMISSION OF SENSITIVE INFORMATION CWE-319 CVSS 3.1HIGH 7.4
Sources
- CVE-2022-1519 · CVE Program
- CVE-2022-1519 · NVD
- FIRST EPSS
- GHSA-4pg3-x42q-599h · GitHub Advisory Database · CC BY 4.0
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